A full-market scan narrowed to the ten biggest moves. Every attribution carries its evidence tier on the badge — first-party filing, press coverage, or an honest blank. Numbers only ever come from first-party sources.
Data updated
2026-08-19 19:36
Instruments scanned
312
Past 24 hours
24 h
All times in UTC
The stories behind the moves
4 stories covering 8 of the tickers on this list.
Story 1Secondary (media)Confidence · Medium
The first mRNA treatment meant to prevent cancer came back with positive Phase 3 results: Moderna +165% in a single session, and 4 tickers riding the same personalized-medicine route were repriced with it. Top comment on r/stocks, 608 upvotes: “Now it's only down 84% on the 5yr.”
MechanismWhat read out is not one drug but a route: sequence the patient's own tumor, pick the mutations worth hitting, manufacture an mRNA vaccine for that single person, then give it after surgery alongside Keytruda to hold recurrence and spread down. The Phase 3 met its primary endpoint — the first time an mRNA cancer vaccine has held up in a late-stage trial. Enrolment size and the formal endpoint names are figures we could not source that day: neither Moderna nor Merck had filed anything with the SEC in the previous four days, so this paragraph stays qualitative and prints no clinical numbers at all — if you cannot click through to a figure from this card, we do not print it. That is also why the repricing did not stop at Moderna: BioNTech runs the rival individualized-mRNA program, Tempus sequences tumors, Iovance sells a personalized cell therapy for melanoma — the market bought the route, not the ticker. The news landed premarket and 3 of the 4 names gapped straight at the bell, so the lag for this cluster cannot be measured and we do not print one.
Event time
2026-08-19 · premarket
Top post at the time
r/biotech366115
Moderna shares jump nearly 100% on skin cancer trial success
wow this huge!! taking a piece of a patient's tumor, mapping its genes and printing a custom mRNA shot to train the body to hunt down remaining cancer cells sounds like sci-fi, but it actually worked…
Estée Lauder printed +18% in one session after earnings — and this time the first-party document was in our hands the same day: before the 13:30 UTC bell the company filed its full-year and fourth-quarter fiscal 2026 results, plus fiscal 2027 guidance, with the SEC itself.
MechanismWhat makes this row worth its own paragraph is not the move, it is that the evidence chain actually closed. First-party sources for a single stock are usually out of reach on the day: an 8-K has a four-business-day grace period, and none of the biotech names on this list had filed anything. But earnings-type 8-Ks are nearly always filed before the bell, and this one was: Estée Lauder's Item 2.02 (results of operations) reached EDGAR ahead of the open, saying the company issued its full-year and fourth-quarter fiscal 2026 results that day along with fiscal 2027 net-sales and per-share guidance. So this catalyst is graded primary and does not have to fall back on press coverage. The cost comes with it: the news was premarket, the move starts exactly on the opening bell (13:30 UTC), the lag cannot be measured and we will not invent one. The sell-side's next-day reaction is not part of this write-up — every one of those notes was published after this snapshot was taken, and citing evidence from after our own timestamp is something we do not do.
Event time
2026-08-19 · premarket
24-hour moves for every ticker in this story, drawn on one shared axis. Every bar is a measurement we took.
Hycroft +15%, DRDGOLD +14%, both gapping on the same opening bell — but what puts them in one story is not a shared headline. It is the industry classification the SEC gives them both — gold and silver ores. Each has news of its own.
MechanismReading this as “gold went up, so gold miners went up” is the natural move, but we hold no gold-price series that would support that sentence, so we do not write it. What we can say: the only thing the two names share is the SEC industry classification for gold and silver ores, and moves of the same order of magnitude — that is all the clustering rests on. The news is separate. Hycroft filed its own 8-K the previous evening (Item 7.01, Regulation FD) reporting a press release with additional drill results from its 2025-2026 exploration drill program; DRDGOLD's side is an MT Newswires write-up of its fiscal 2026 results, published before the bell. Each explains one half of the pair, and the number of candidate articles that would explain both is 0. So the story-level badge takes the weaker of the two legs rather than letting Hycroft's filing vouch for DRDGOLD. Both gapped at the opening bell, so the lag here is not measurable either.
Event time
2026-08-18 · premarket
24-hour moves for every ticker in this story, drawn on one shared axis. Every bar is a measurement we took.
Twist +21% in a session — and not on the mRNA vaccine readout next door. Its own 8-K says it plainly: Anthropic picked Twist as one of the independent evaluators for its AI-designed proteins.
MechanismThe easy mistake on a day like this is to fold it into the vaccine cluster: a handful of tickers up hard in the same direction really does look like one trade. But not one piece of Twist's own evidence mentions a vaccine. Its 8-K from 22:15 UTC the previous evening (Item 7.01, Regulation FD) reports that Anthropic got data back on a multi-arm protein design campaign against 15 targets and chose Twist as one of its independent evaluators; the MT Newswires confirmation later that session says the same thing; even the dissenting Stocktwits piece is arguing about Anthropic's drug-discovery claims. The buyer base for synthetic DNA widening from vaccine makers to model labs is its own reason to reprice, and it should not borrow anyone else's badge. It gapped at the open too (13:30 UTC), so the lag is again not measurable.
Event time
2026-08-18 · premarket
24-hour moves for every ticker in this story, drawn on one shared axis. Every bar is a measurement we took.
Last 24 hourly closes · 1H · Move started 2026-08-19 13:30
Moderna, Inc.
Last price
166.83 USD
Change
+164.97%
Intraday range
45.84%
Volume vs baseline
166.1×
Sigma move
38.4 σ
Rank in past 100 days
#1
Move started
2026-08-19 13:30The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Part of this storySecondary (media)Confidence · Medium
24/7 Wall St. report. MRNA gapped at the bell and rose 165.0% over 24 hours on 166.1× baseline volume — the news broke pre-market, so the lag cannot be measured.
Event time
2026-08-19 · premarket
Lag
n/a
The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Timeline from the release to the volume break. Both timestamps come from machine-readable first-party feeds; the gap between them is the lag.The last 24 hourly closes, pre/post-market included. US equities are shut for most of the day; the gaps in the axis are real and are not filled in.
Sources
Measured from
Price, volume and range for this row are measured here.
Only the move-start marker. No first-party event in the window lines up on both timing and scope, so the left-hand side stays empty.The last 24 hourly closes, pre/post-market included. US equities are shut for most of the day; the gaps in the axis are real and are not filled in.
Sources
Measured from
Price, volume and range for this row are measured here.
Last 24 hourly closes · 1H · Move started 2026-08-19 13:30
Twist Bioscience Corporation
Last price
140.12 USD
Change
+20.69%
Intraday range
10.70%
Volume vs baseline
9.7×
Sigma move
3.7 σ
Rank in past 100 days
#1
Move started
2026-08-19 13:30The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
TWST filed Form 8-K with the SEC (Item 7.01 Regulation FD disclosure). TWST gapped at the bell and rose 20.7% over 24 hours on 9.7× baseline volume — the news broke pre-market, so the lag cannot be measured.
Event time
2026-08-18 · premarket
Lag
n/a
The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Timeline from the release to the volume break. Both timestamps come from machine-readable first-party feeds; the gap between them is the lag.The last 24 hourly closes, pre/post-market included. US equities are shut for most of the day; the gaps in the axis are real and are not filled in.
Sources
Measured from
Price, volume and range for this row are measured here.
Last 24 hourly closes · 1H · Move started 2026-08-19 13:30
BioNTech SE
Last price
111.68 USD
Change
+20.41%
Intraday range
8.23%
Volume vs baseline
62.3×
Sigma move
15.5 σ
Rank in past 100 days
#1
Move started
2026-08-19 13:30The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Part of this storySecondary (media)Confidence · Medium
24/7 Wall St. report. BNTX gapped at the bell and rose 20.4% over 24 hours on 62.3× baseline volume — the news broke pre-market, so the lag cannot be measured.
Event time
2026-08-19 · premarket
Lag
n/a
The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Timeline from the release to the volume break. Both timestamps come from machine-readable first-party feeds; the gap between them is the lag.The last 24 hourly closes, pre/post-market included. US equities are shut for most of the day; the gaps in the axis are real and are not filled in.
Sources
Measured from
Price, volume and range for this row are measured here.
Last 24 hourly closes · 1H · Move started 2026-08-19 15:00
Hyperliquid
Last price
70.28 USD
Change
+19.49%
Intraday range
24.49%
Volume vs baseline
18.1×
Sigma move
7.4 σ
Rank in past 100 days
#1
Move started
2026-08-19 15:00
UnattributedConfidence · Low
Up 19.5% over 24 hours on 18.1× baseline volume — no first-party event in the window lines up on both timing and scope.
Nothing in the window before the move began lines up on both timing and scope — not a first-party filing, not a press report. We would rather leave this blank than supply a reason that merely sounds plausible.
Only the move-start marker. No first-party event in the window lines up on both timing and scope, so the left-hand side stays empty.The last 24 hourly closes. Crypto trades 24/7, so the axis has no gaps.
Sources
Measured from
Price, volume and range for this row are measured here.
Last 24 hourly closes · 1H · Move started 2026-08-19 13:30
The Estée Lauder Companies Inc.
Last price
99.39 USD
Change
+17.94%
Intraday range
6.22%
Volume vs baseline
18.5×
Sigma move
10.7 σ
Rank in past 100 days
#1
Move started
2026-08-19 13:30The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
EL filed Form 8-K with the SEC (Item 2.02 results of operations). EL gapped at the bell and rose 17.9% over 24 hours on 18.5× baseline volume — the news broke pre-market, so the lag cannot be measured.
Event time
2026-08-19 · premarket
Lag
n/a
The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Timeline from the release to the volume break. Both timestamps come from machine-readable first-party feeds; the gap between them is the lag.The last 24 hourly closes, pre/post-market included. US equities are shut for most of the day; the gaps in the axis are real and are not filled in.
Sources
Measured from
Price, volume and range for this row are measured here.
Last 24 hourly closes · 1H · Move started 2026-08-19 01:00
DOS
Last price
0.2664 USD
Change
+16.25%
Intraday range
22.78%
Volume vs baseline
5.2×
Sigma move
n/a
Rank in past 100 days
n/a
Move started
2026-08-19 01:00
UnattributedConfidence · Low
Up 16.3% over 24 hours on 5.2× baseline volume — no first-party event in the window lines up on both timing and scope.
Nothing in the window before the move began lines up on both timing and scope — not a first-party filing, not a press report. We would rather leave this blank than supply a reason that merely sounds plausible.
Only the move-start marker. No first-party event in the window lines up on both timing and scope, so the left-hand side stays empty.The last 24 hourly closes. Crypto trades 24/7, so the axis has no gaps.
Sources
Measured from
Price, volume and range for this row are measured here.
Last 24 hourly closes · 1H · Move started 2026-08-19 13:30
Hycroft Mining Holding Corporation
Last price
27.82 USD
Change
+15.01%
Intraday range
6.98%
Volume vs baseline
4.9×
Sigma move
2.7 σ
Rank in past 100 days
#2
Move started
2026-08-19 13:30The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
HYMC filed Form 8-K with the SEC (Item 7.01 Regulation FD disclosure). HYMC gapped at the bell and rose 15.0% over 24 hours on 4.9× baseline volume — the news broke pre-market, so the lag cannot be measured.
Event time
2026-08-18 · premarket
Lag
n/a
The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Timeline from the release to the volume break. Both timestamps come from machine-readable first-party feeds; the gap between them is the lag.The last 24 hourly closes, pre/post-market included. US equities are shut for most of the day; the gaps in the axis are real and are not filled in.
Sources
Measured from
Price, volume and range for this row are measured here.
Last 24 hourly closes · 1H · Move started 2026-08-19 13:30
Iovance Biotherapeutics, Inc.
Last price
8.0450 USD
Change
+14.44%
Intraday range
12.03%
Volume vs baseline
5.3×
Sigma move
1.5 σ
Rank in past 100 days
#5
Move started
2026-08-19 13:30The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Part of this storySecondary (media)Confidence · Medium
The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Only the move-start marker. No first-party event in the window lines up on both timing and scope, so the left-hand side stays empty.The last 24 hourly closes, pre/post-market included. US equities are shut for most of the day; the gaps in the axis are real and are not filled in.
Sources
Measured from
Price, volume and range for this row are measured here.
Last 24 hourly closes · 1H · Move started 2026-08-19 13:30
DRDGOLD Limited
Last price
27.80 USD
Change
+14.40%
Intraday range
3.42%
Volume vs baseline
9.3×
Sigma move
4.8 σ
Rank in past 100 days
#1
Move started
2026-08-19 13:30The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Part of this storySecondary (media)Confidence · Medium
MarketBeat report. DRD gapped at the bell and rose 14.4% over 24 hours on 9.3× baseline volume — the news broke pre-market, so the lag cannot be measured.
Event time
2026-08-19 · premarket
Lag
n/a
The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
Timeline from the release to the volume break. Both timestamps come from machine-readable first-party feeds; the gap between them is the lag.The last 24 hourly closes, pre/post-market included. US equities are shut for most of the day; the gaps in the axis are real and are not filled in.
Sources
Measured from
Price, volume and range for this row are measured here.
First-partyA machine-readable endpoint run by the issuer, the exchange or the regulator itself.
Cross-verifiedTwo mutually independent sources report the same figure.
Secondary (media)Press coverage. Listed as a lead only; its figures never enter a measured field.
UnattributedNo catalyst was found. That is the normal case, not a failure.
Change
For crypto this is the exchange's rolling 24-hour figure (last price over the price 24 hours ago). For US equities it is the session change, previous close to last: US markets are shut about 17.5 hours a day, so a literal 24-hour window would fold two sessions into one number.
Volume vs baseline
Volume of the breakout bar divided by the median of the prior 20 bars. The baseline is a median, not a mean, so the spike cannot inflate its own denominator.
Sigma move
This move measured in standard deviations of the instrument's own 30-day realised volatility. The larger the number, the less it looks like ordinary noise.
Rank in past 100 days
Where this move ranks among the past 100 complete trading days. Rank 1 means the biggest in a hundred sessions.
Lag
Time between the catalyst event and the start of the move. If the event lands after the move began, the entry is marked unattributed.
Gap at the open
The news broke before the bell, so the repricing was finished by the time trading opened. This row's move starts at the opening bell itself, which means there is no lag to measure — and we do not print one.
